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Selected scientific articles authored by Dr Holm,
see the entire publication list here
1. Treatment in the primary sector with the following effects:
74% of patients reduce degree of obesity
See the paper here
Improvement of quality of life
See the paper here
Reduction in blood pressure
See the paper here
Reducing obesity and increasing quality of life, physical activity, mood, body perception and reducing appetite and bullying with the digital solution DrHolmApp
2. Treatment in the secondary sector with the following effects:
69% and 75% reduce degree of obesity
See paper 1 here
See paper 2 here
Reduction in cholesterol levels
See paper 1 here
Reduction of fatty liver and muscle fat
Parents reduce degree of obesity
90% achieve improvements in cholesterol levels, degree of obesity, and lean body mass
Equally effective treatment response despite familiar predispositions to obesity related comorbidities
Equally effective treatment response despite impaired glucose metabolism
Equally effective treatment response despite a genetic risk score composed of 15 commonly occurring genes with impact on development of obesity in children and youth
Equally effective treatment response despite disturbed eating behavior
Reduction of sleep apnea
Equally effective treatment response independent of gestational age, birth weight and birth length
Se the paper here
Reduce degree of obesity and concomitantly improve 142 lipids in 85 % of patients
Danish recommendations based on this method
International recommendations for the treatment of youth with obesity
3. Obesity related complications in children and adolescents
27% exhibit dyslipidemia
31% exhibit liver and 66% exhibit muscle steatosis
See paper 2 here
See paper 3 here
See paper 4 here
50% exhibit pre- or overt hypertension
10,4% exhibit subclinical hypothyroidism
16,5% exhibit vitamin D deficiency
44% exhibit sleep apnea
14% exhibit prediabetes
4. Medication to children and adolescents with obesity
Patients with MC4R mutations are more difficult to treat
Patients with MC4R mutations (heterozygous) can be treated with medicine
Inconsistencies in dosage of medication in children and youth with obesity
Patients with MC4R mutations (homozygous) can be treated with medicine
5. Genetic aspects of childhood obesity
Identification of 3 new genes with impact on obesity in children and youth
Genetic risk score describing insulin sensitivity, metabolic disease and altered fat distribution
Genetics and thyroid hormones
Genetics, birth weight and cardiovascular disease later in life
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
2 new genes
6. Pregnancy and early growth
Affected birth weight and length of pregnancy
Obesity related markers of gestational diabetes
Association between birth weight, degree of obesity, and body composition
PCOS and obesity
7. Other effects of childhood obesity
The gut microbiome can induce obesity
Physical activity in children and adolescents with obesity
Investigation of sensory-specific satiety
8. Markers of childhood obesity
Reference values for markers of obesity and comorbidities
Changes in markers of obesity and comorbidities following obesity treatment
See paper 3 here
Relation between high blood glucose and obesity related comorbidities
9. Regarding obesity as a chronic disease and the lack of available treatment options
Position statement for declaring obesity as a chronic disease in Europe
Lack of available treatment clinics in Denmark
Proposal for new diagnostic criteria for obesity
10. Treatment and ethics
The ethics in childhood obesity treatment
11. COVID-19
Obesity and COVID-19 from The European Association
Obesity, COVID-19 and the immune system from The European Association
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